Controlled release drug delivery systems are gaining importance in the last few decades for their clinical benefits which are not obtained from conventional oral drug delivery. Hydrophilic matrices involving natural polysaccharides are an interesting option for developing sustained release formulation. One of such polysaccharides is Tamarind seed polysaccharide (TSP) isolated from seed kernel of Tamarindus indica. Although TSP is used as an ingredient in food materials, it has not been extensively evaluated till date for its utility in pharmaceuticals formulations. So, this review mainly focuses on the utility of TSP as an excipient in novel drug delivery systems.