Abstract

OXIDATIVE STRESS AND ANTIOXIDANT STATUS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION IN MGM HOSPITAL WARANGAL (A.P)

Cardiovascular diseases account for 12 million deaths annually worldwide. Myocardial infarction continues to be a significant problem in industrialized countries and is becoming an increasingly significant problem in developing countries. Oxidative modification of circulating lipids contributes to inflammation and endothelial dysfunction which are the hallmark features of atherosclerosis. The study was designed to determine the lipid peroxidation and antioxidant status in patients with Acute Myocardial Infarction (AMI). The Mahatma Gandhi Memorial Hospital is a 1000 bedded multidisciplinary tertiary care government hospital in Andhra Pradesh. The study was carried out in 30 patients and their data were collected from inpatients records available in emergency department of the hospital. All patients’ blood samples were collected after obtaining the informed consent form. All the data has been analyzed using graph pad prism version 5 and the P < 0.05 is considered to be significant. Our results show that the mean age of the patients was 54.57±2.08 years, whereas the most predominant age group was found to be 41-50 years. The risk factors for AMI observed in our study were alcohol (80%), smoking (43%), hypertension (43%), diabetes (37%), and sedentary lifestyle (24%). The levels of Malondialdehyde (MDA), which is a biomarker for oxidative stress was found to be 25.38 ± 3.59 nM/ml (P = 0.0206). Glutathione, the cell’s natural antioxidant was found to be 6.25 ± 0.61 µg/ml (P < 0.001). Total antioxidant level was found to be 26.35 ± 2.97 µg/ml (P = 0.0416). In the present study there was an enhanced oxidative stress and decreased antioxidant status. Our results elaborate the significance of oxidative stress and emphasis the use of antioxidants may be beneficial in the treatment as shown in animal models. Further clinical studies are required to be conducted to elucidate the role of oral antioxidants in AMI