Antibiotic utilization review can be used to compare the observed prescribed drug use for the treatment of a certain disease with current recommendations or guidelines, deviation from standard guidelines. To study the Prescribing Patterns of antibiotics, and risk factors in Respiratory tract infections.It was single centered, observational study conducted by random selection of patients. Based on diagnosis, the study population was categorized into 8 groups: asthma COPD, Pneumonia, Tuberculosis sinusitis, pharyngitis, tonsillitis and other disease conditions. The study population was interviewed after obtaining verbal informed consent for information on the risk factors, and other pertinent information like demographics, diagnosis, treatment and drug utilized. Of the total 120 patients included in the study, 55% were male and 45% were female. Total no. of antibiotics prescribed during the study period was 174. Most commonly prescribed drug was name ceftriaxone (class: cephalosporin). The study revealed that the prescribing pattern was partially in accordance with referred literature. Most commonly prescribed antibiotic was ceftriaxone (cephalosporin’s), the average percentage of antibiotics utilization was found to be highest in pneumonia. The highest risk factor among all the individuals was tobacco use (18.18%). The highest risk factor in males was tobacco use (28.7%) .The highest risk factor in females was Diabetes mellitus (23.86%).