A 31year of female patient with 8 week 6 days of G1P0L0A0 obstetric status were admitted in gynecology department of tertiary care teaching hospital with chief complaints of sever back pain, abdominal pain and vaginal bleeding. Patient had history of passage of flesh mass. There was no history of Hypertension, Diabetes Mellitus and Asthma. On admission patient was conscious and oriented. Vaginal examination by USG pelvis shows uterus was 8 week and 6 days with OS closed and product of conception was felt in uterus. Patient diagnosed to have incomplete abortion. On admission patient symptoms were managed with Inj. Tranexamic acid (1g) Intravenous in 100 ml NS stat and Inj. Tramadol Hydrochloride 50mg stat. second day onwards patient were treated with Tab Misoprostol 100mcg/vaginum/day for expelling of the retained product from uterus. On third day after examination D and C were suggested, for that prophylactic antibiotic treatment was started with Inj. Ciprofloxacin 200mg/ 100ml. after the first dose of ciprofloxacin immediately patient presented allergic reaction all over the body, face and palm associated with itching, rashes and breathlessness. Suddenly stopped the medication and treated with Inj. Chlorpheneramine Maleate25mg/2ml and Inj. Dexamethasone 8mg IV stat. The anaphylactic reactions are rare adverse drug reaction of Ciprofloxacin and other Fluroquinolone. Medical practitioner and other Para-medical staff should be aware of this potentially fatal event to avoid possible adverse drug event due to cross sensitivity among Fluroquinolone during administration.