Purpose of the SOP is to carry out the operations correctly and always in the same manner. It should be available at the place where the work is done. The SOP is a compulsory instruction. All changes in the instructions must be documented and reported to the authorities who are the only ones to authenticate and approve such variations. To establish the SOPs to Siddha Drug. Research drug: Uththara Rasa Chendooram (URC) by the reference of Hakeem Abdul Sahib. B.M, “Anuboga Vaidya Navaneetham”–Part-5. Preparation: Purified all raw materials initially. Then, powdered all separately and carry out VI steps in total procedures. Step I: Grinding the Rasam and Gandhgam and got Black fine mixer. Step II: Grinding the other ingredients of drug with black mixer and mixed well. Step III: Ingredient mixer ground with juice of seruppadai juice. Step IV: Ingredient mixer grind with juice of katralai. Step V: Ingredient mixer ground with juice of maathulai leaves. Step VI: Dry powder kept into glass kaasicuppi sealed with gasket -21 times Mud apparatus. Step VII: Mud sealed apparatus under went to fire for 72 hours with sand cover apparatus (vaalukayantra). Finally ground final product of URC and kept it into air tied black glass sealed container to prescribe to patients. According to this research objectives reached successfully with actual time frame and perfection of every operating procedures with standard. Therefore, this research was proved SOPs of Uththara Rasa Chendooram (URC) perfectly in 29 days.