The key factors to promote and maintain good health throughout the life are diet and nutrition. Chronic diseases that are related to imbalance in the diet and nutrition are diabetes mellitus, cardiovascular disease, stroke, obesity, cancer, osteoporosis and dental diseases. In 2001, 60% of the total deaths among 56.5 million people is mainly due to chronic diseases contributed approximately 46% of the global burden of disease. Aims & Objectives: To compare the behavior of anti-diabetic drugs given in two combinations in patients with diabetes mellitus type II. To assess the safety and efficacy of Metformin plus Teneligliptin in patients with type II diabetes mellitus. Methodology: The 100 subjects have been recruited for the current study grouped into two and studied Under Prospective cohort study. Result: A total of 100 patients completed all the follow up visits. Patients enrolled were known case of diabetes mellitus type II, with no co morbid conditions and have been administered with either of the drug combinations of our study. Discussion & Conclusion: Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. When compared between Metformin plus Teneligliptin and Metformin plus Glimepiride, the former combination is better in terms of efficacy. Irrespective of the therapy regimen, proper monitoring is needed to check the patient for not being hypoglycemic especially in cases of sulfonylureas.