India is the country that leads the world with maximum number of Diabetic patients being called as the "Diabetes capital of the world." International Diabetes Federation published Diabetes atlas 2006, according to it, the number of people with Diabetes in India currently around 40.9 million & by 2025 it was by expected to increase to 69.9 million when preventive measures are not taken urgently. Aim and Objectives: To evaluate the health related life style establishment in Type II Diabetes Mellitus patients. Assess the effect of dietary interventions and life style modifications in (T2DM) patients on clinical signs and symptoms with biochemical parameters. Results: There is convincing evidence for a decreased risk of Diabetes in adults who are physically active and maintain a normal body mass index (BMI) throughout adulthood, and in overweight adults with impaired glucose tolerance who lose weight voluntarily. An increased risk for developing type 2 Diabetes is associated with overweight and obesity; abdominal obesity; physical inactivity; and maternal Diabetes. It is probable that a high intake of saturated fats and intrauterine growth retardation also contribute to an increased risk, while non-starch polysaccharides are likely to be associated with a decreased risk. From existing evidence, it is also possible that omega-3 fatty acids, low glycemic index foods and exclusive breastfeeding may play a protective role, and that total fat intake and trans fatty acids may contribute to the risk. However, insufficient evidence is currently available to provide convincing proof. Discussion: This chapter deals with discussion part to the results, obtained from statistical analysis based on the data of the study, the reviewed literature, hypothesis which was selected for the study. The purpose of the study was to “Evaluate life style establishment in Type 2 Diabetic Patients attending RVS Multi specialty hospital, Chittoor”. It was presented in the view of the objectives of the study. Conclusions: Based on the strength of available evidence regarding diet and lifestyle in the prevention of type 2 diabetes, it is recommended that a normal weight status in the lower BMI range (Body Maas Index 21–23) and regular physical activity be maintained throughout adulthood; abdominal obesity be prevented; and saturated fat intake be less than 7% of the total energy intake