Diabetic neuropathy (DN) is one of the most common and disabling complications of diabetes mellitus, which has a serious adverse effect on the quality of life of patients. The management of DN involves a complex, evidence-based approach that combines the pharmacological management, non-pharmacological management, and lifestyle change. Evidence-based pharmacy practice is paramount in improving the treatment regimens, proper use of drugs, and reduction of the side effects. Pharmacists are also part of the healthcare team and this body gives experience in the management of medications, observe side effects, and train the patients to take care of themselves and adhere to the medications. This practice can be useful in enhancing the patient outcomes, reducing the neuropathic pain, and preventing the disease progression. Pharmacological treatment, which includes anticonvulsants, antidepressants, and topical agents, is usually employed in the treatment of DN symptoms with non-pharmacological interventions such as physical therapy, exercise, and cognitive-behavioral therapy being rather beneficial. Moreover, lifestyle changes such as glycemic regulation, weight loss, and smoking are also helpful to the general efficacy of therapy. The future of the DN care is bright with the development of neuroprotective therapies, gene therapy, and personalized medicine. The pharmacists are critical in keeping abreast of the new treatments and making sure that they are incorporated into practice. The abstract shows the relevance of an evidence-based patient-centered intervention to diabetic neuropathy management, and pharmacists are the best to improve patient care and optimize the therapeutic results.