Subclinical thyroid dysfunction refers to patients who have an abnormal thyrotropin (thyroid-stimulating hormone [TSH]) level and a normal free thyroxine (T4) level. The objective of the present study to review to describe the current drug therapy, pathogenesis, clinical manifestation and risk factors of subclinical thyroid hypothyrodism. We conducted a search of the Kakatiya University library (UCPSc) for article published between 2000 and 2012. Using the key phrases; epidemiology, thyroid disease, drug interaction, clinical manifestation, diagnosis, pharmacological and non-pharmacological therapy. All relevant publications were retrieved and their bibliography was scanned for additional sources. The process of selecting articles involved three stages; i) Title review ii) Abstract review and iii) Article review, with specific rejection criteria for each of these stages. Generally studies were excluded if they i) were not written in English ii) were presented only in abstract form iii) literature review not focused on human or human cells. Our article suggests that, more research should be carried out in therapeutic management of hypothyroid disease.