Nevirapine – NRTI’s licensed for first line drug regimen in HIV infections. It is relatively non-toxic in nature and potentially antiviral effects of other NRTI’s like Lamivudine although Nevirapine is a well-tolerated, certain (dermatological) cutaneous side effect like skin rash. We report a case series of skin rashes in 3 HIV infected paediatric patients, probably due to Nevirapine. Adverse cutaneous drug reactions are distressing to both the patient and physician. Mortality can occurs in severe reactions, but even without this quality of life may be significantly diminished due to hospitalization, prolongation of hospital stay and increased morbidity, Furthermore, the development of a skin eruption is frequently cite and as a reason for discontinuation of treatment without completing therapeutic course.