Facial melanosis defines as hyperpigmentation and frequently brown to black area about the face especially brow and cheek cause undesirable looking and losing the self-confident. Several current treatments have been used to combat melisma. We have selected glutathione soap for the treatment of facial melanosis. Glutathione reduces the production of melanin which is responsible for dark pigment in skin color. Glutathione is an effective treatment to lighten skin, improve melasma (mask of pregnancy) and neutralize hyperpigmentation. To study the effectiveness of glutathione in the treatment of melanosis condition on face. 15 patients with facial melanosis were included in the study as per the inclusion and exclusion criteria. Written informed consent was taken for their participation in the study. Detailed history including name, age, sex, address, contact number, marital status, occupation and history of medication were noted. Photographs were taken prior after the usage for documentation. Out of 15 patients who are taken treatment for facial melanosis with glutathione soap followed for 3months and there is decrease in the hyperpigmentation in 11 patients. Our study results showed that glutathione, when used as soap, has a skin lightening effect.