Hyperlipidemia has been ranked as one of the greatest risk factors contributing to the prevalence and severity of coronary heart diseases. Major complications of hyperlipidemia are atherosclerotic heart disease, heart attack, stroke, atherosclerosis and hyperlipidemia which are also the primary cause of death. Cow is a mobile dispensary. It is the treasure of medicines. The cow urine therapy is capable of curing several curable and incurable diseases. The holy texts, such as Atharva Veda, Charak Samhita, Rajni Ghuntu, Vridhabhagabhatt, Amritasagar, Bhavprakash and Sushrut Samhita, contain beautiful description about these things. We have evaluated the antihyperlipidemic activity of cow urine in rats and in healthy volunteers and results indicated significant activity in both models.