Grace College of Pharmacy, Kodunthirapully, Palakkad – 678 004, Kerala, India

Grace College of Pharmacy, Kodunthirapully, Palakkad – 678 004, Kerala, India

Grace College of Pharmacy, Kodunthirapully, Palakkad – 678 004, Kerala, India

Grace College of Pharmacy, Kodunthirapully, Palakkad – 678 004, Kerala, India

Grace College of Pharmacy, Kodunthirapully, Palakkad – 678 004, Kerala, India
Mucoadhesion ,microspheres ,bioavailability ,

Carrier technology provides an interesting as well as an intelligent approach for the delivery of drug. It offers delivery of drug by coupling the drug to a carrier particle such as microspheres, nanoparticles, liposome, etc. Microspheres constitute an important part of novel drug delivery system by virtue of their small size and efficient carrier capacity. Due to their short residence time, bioadhesive characteristics can be coupled to microspheres to develop mucoadhesive microspheres. Bioadhesion has been defined as the attachment of synthetic or biological macromolecules to a biological tissue. The biological surface can be epithelial tissue or the mucous coat on the surface of a tissue. By the use of mucoadhesive polymers, microspheres can adhere to the epithelial surface in the stomach. Microspheres having particle size is ranges from 1-1000 µm range in diameter having a core of drug and entirely outer layers of polymer as coating material. Mucoadhesive microspheres have advantages like efficient absorption and enhanced bioavailability of the drugs due to a high surface to volume ratio, a much more intimate contact with the mucus layer, controlled and sustained release of drug from dosage form and specific targeting of drugs to the absorption site. The present study aims to provide an overview of various aspects of mucoadhesive microsphere based on various polymers, methodology of preparation of mucoadhesive microspheres, method of evaluation and their applications in drug delivery

7 , 1 , 2017