Dept. of Pharmacy, Sri Venkateswara University S. V. U. College of Pharmaceutical Sciences, Tirupati-517501, Andhra Pradesh, India

Asst. Professor, Dept. of Pharmacy, Sri Venkateswara University S. V. U. College of Pharmaceutical Sciences, Tirupati-517501, Andhra Pradesh, India

Asst. Professor, Dept. of Pharmacy Practice, Sri Venkateswara College of Pharmacy, RVS, Nagar, Tirupati Road, Chittoor-517127, Andhra Pradesh, India

Asst. Professor, Dept. of Pharmaceutical Drug Regulatory Affairs, Sri Venkateswara College of Pharmacy, RVS, Nagar, Tirupati Road, Chittoor-517127, Andhra Pradesh, India
Antiulcer ,Gliricidia Sepium ,Thin Layer Chromatography ,

Peptic ulcer disease is a group of disorders characterized by the presence of ulcers in any portion of gastrointestinal tract (GIT) exposed to acid in sufficient concentration and duration. Although these ulcerations most commonly occur in the stomach (gastric ulcer), or small intestine (duodenal ulcer), this disease also includes Barrett ulcer of the esophagus (Barrett?s esophagus or Barrett?s metaplasia) and other upper gastrointestinal ulcers. An ulcer is a crater like lesion in a membrane; ulcers that develop in areas of the GIT exposed to acidic gastric juice are called peptic ulcers. Word „peptic? derives from the Greek term „peptikos,? meaning related to digestion. The word „peptic? refers to pepsin a stomach enzyme that break down proteins. Peptic ulcer located in stomach is called gastric ulcer. Peptic ulcer disease (PUD), also known as a peptic ulcer or stomach ulcer, is a break in the lining of the stomach, first part of the small intestine, or occasionally the lower esophagus. Aim & Objectives: To determine the Gastro protective effect of ethanolic extract of Gliricidia septum. Extract the active phytochemical constituents from the selected medicinal plant with the solvent Ethanol. Identification of phytochemical constituents present in extract i. e., responsible for the activity by Thin Layer Chromatography (TLC). Method: Healthy Albino Wistar rats weighing 150-200g were obtained from the animal house of Sri Venkateswara College of Pharmacy, Chittoor, and Andhra Pradesh. The animals were maintained in a well-ventilated room with 12:12 hour light/dark cycle in polypropylene cages. The animals were fed with standard pellet feed (Hindustan Lever Limited, Bangalore) and water was given ad libitum. The experimental protocol was approved by the Institutional Animal Ethical Committee (IAEC). The fresh leaves of the plant Gliricidia sepium (Fabaceae) were collected as per the guidance of the botanist & air dried & reduced to coarse powder. The air-dried powdered plant material (200gm) was extracted with Ethanol by using soxhlet apparatus for 3 days. Then the concentrated extracts were kept in desiccators and were used for further experiment. Each extract was weighed and its percentage in terms of air-dried weight of plant material was calculated and also the consistency of the extracts was noted. Result: The present study gives an emphasized data which helps to consider the medicinal plant Gliricidiasepium as a potent Anti-ulcer agent with the help of the data retried like the ethanolic extract of leaves of Gliricidiasepium has shown the presence of phytochemical constituents like Alkaloids, flavonoid, phenols, terpinoids in (Table: 4, 5, 6, 7). Conclusion: With the help of the studies carried out the ethanolic extract of leaves of Gliricidiasepium seemed to be reliable and could be used as a potent anti ulcer agent. Over the years an increasing number of studies are involved in the acetic acid models have been undertaken to strive towards both clarification of the mechanisms involving the ulcer healing and discovery of antiulcer agents.

11 , 2 , 2021