Sree Vidyanikethan College of Pharmacy, Tirupati, Andhra pradesh, India.
Artificial blood ,Haemoglobin-based oxygen carriers ,Perfluorochemicals ,

Artificial blood is a product made to act as a substitute for red blood cells, blood substitutes are used to fill fluid volume and/or carry oxygen and other blood gases in the cardiovascular system. More accurate terms are volume expanders for inert products, and oxygen therapeutics for oxygen-carrying products. Ideal blood substitute should have Universal compatibility: elimination of cross matching, Pathogen free, Minimal side effects, Survivability over a wider range of storage temperatures, Long shelf life, Cost efficient etc. Their main function is replacing lost blood volume and oxygen carrying capacity. Haemoglobin-based oxygen carriers vaguely resemble blood. They are very dark red or burgundy and are made from real, sterilized hemoglobin, which can come from a variety of sources. Unlike haemoglobin-based oxygen carriers, perfluorochemicals are usually white and are entirely synthetic. This review discussed there are several promising techniques like stem cells, dendrimers, biodegradable micelles and from placental umbilical cords (for artificial blood synthesis. Future scope of artificial blood is it is used in case of transfusion transmitted diseases. It’s concluded that large-scale production of blood substitutes would also help to meet the anticipated increase in demand for blood.

2 , 1 , 2012